MC-Val-Cit-PAB-PNP
MC-Val-Cit-PAB-PNP is a high-purity, cleavable linker designed for drug conjugation, featuring a maleimidocaproyl (MC) group for thiol-specific coupling and a para-aminobenzyl p-nitrophenyl carbonate (PAB-PNP) for payload attachment. The valine–citrulline (Val-Cit) dipeptide sequence enables especially selective cleavage by cathepsin B, allowing controlled release of the payload in targeted delivery systems. This design is specifically used in antibody–drug conjugates (ADCs) and other targeted therapeutics.
Key Features and Benefits
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MC Group: Maleimidocaproyl moiety selectively couples to thiols, forming stable thioether bonds.
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Val-Cit Cleavable Linker: Enzyme-cleavable by cathepsin B for targeted drug release.
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PAB-PNP Moiety: Activated carbonate for efficient payload attachment via hydroxyl or amine groups.
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Cleavable Design: Enables site-specific release of active drug in the target environment.
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High Purity: Supplied at >95% purity for reproducible conjugation results.
Applications
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Antibody–Drug Conjugates (ADCs): Attach cytotoxic payloads to antibodies with controlled release.
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Targeted Drug Delivery: Facilitate selective release within diseased tissues.
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Prodrug Development: Engineer therapeutics with enzyme-triggered activation.
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Nanoparticle Conjugation: Link drugs to nanoparticle carriers with cleavable functionality.
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Diagnostic and Imaging Probes: Create probes with triggered release for enhanced specificity.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture to preserve reactivity.
MC-Val-Cit-PAB-PNP combines thiol-specific conjugation with an enzyme-cleavable linker and an activated carbonate payload attachment site, offering precision specifically for targeted therapeutics, diagnostics, and drug delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
