MC-Val-Cit-PAB-OH
MC-Val-Cit-PAB-OH is a high-purity cleavable linker with a maleimidocaproyl (MC) group for thiol-specific conjugation, a cathepsin B–cleavable Val-Cit dipeptide, and a para-aminobenzyl (PAB) self-immolative spacer for payload release. The design ensures stability in circulation and controlled intracellular release, making it especially ideal for antibody–drug conjugates (ADCs), targeted therapeutics, and diagnostic probes.
Key Features and Benefits
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MC (Maleimidocaproyl) Group: Selectively reacts with thiols to form stable thioether bonds under mild conditions.
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Val-Cit Cleavable Linker: Stable in systemic circulation and cleaved by cathepsin B inside target cells.
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PAB Self-Immolative Spacer: Triggers rapid and complete payload release after enzymatic cleavage.
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Optimized Linker Length: Balances stability with efficient enzymatic access.
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High Purity: Supplied at >95% purity for reproducible, high-yield performance.
Applications
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Antibody–Drug Conjugates (ADCs): Link antibodies to cytotoxic drugs for targeted cancer therapy.
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Peptide–Drug Conjugates: Enable site-specific, enzyme-triggered payload release.
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Nanoparticle Functionalization: Add cleavable linkers for targeted delivery.
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Prodrug Development: Incorporate linkers that activate in disease-specific environments.
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Diagnostic Probe Development: Create targeted imaging agents with controlled release.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve maleimide reactivity.
This product combines thiol-reactive MC chemistry with a cathepsin B–cleavable Val-Cit linker and a PAB spacer for stable circulation and an especially efficient intracellular payload release in ADCs and other targeted delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
