MC-Val-Ala-PAB-OH
This product is a protease-cleavable linker containing a Val-Ala dipeptide and a self-immolative PAB spacer, designed for controlled drug release in ADCs and targeted delivery systems. Its structure ensures selective cleavage specifically by lysosomal enzymes and efficient, traceless payload release.
Key Features and Benefits:
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Protease-Cleavable Linker: Val-Ala dipeptide ensures selective cleavage in lysosomal environments.
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Self-Immolative PAB Spacer: Facilitates efficient and traceless payload release.
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Maleimidocaproyl (MC) Handle: Provides thiol-reactive functionality for site-specific conjugation.
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High Purity: Ensures reproducibility in ADC and bioconjugation workflows.
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Versatile Use: Suitable for a wide range of therapeutic and diagnostic applications.
Applications:
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Antibody-Drug Conjugates (ADCs): Widely used as a linker for payload release inside target cells.
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Targeted Drug Delivery: Provides controlled drug release via enzymatic cleavage.
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Bioconjugation Research: Serves as a model linker in linker-payload development studies.
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Prodrug Strategies: Enables selective activation of therapeutic molecules in diseased tissues.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) and handle under inert conditions when possible.
This product is a gold-standard linker for ADC development, specifically offering protease-triggered cleavage and efficient drug release through its self-immolative design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
