Name: MC-MMAF
SKU: AP14195
Availability: InStock

MC-MMAF

$350.00 – $1,250.00

MC-MMAF combines the MC linker with MMAF, a synthetic antineoplastic agent. The Mal group on the linker reacts with thiol groups, allowing targeted attachment to antibodies. MMAF disrupts tubulin polymerization, effectively killing cancer cells. Used in antibody-drug conjugates (ADCs), MC-MMAF delivers powerful anticancer effects with precision.

Unit

Price

Quantity

5mg

$350

10 mg

$470

25 mg

$780

50 mg

$1250

Would you like to inquire about bulk pricing?

SKU: AP14195 Category: Val-Cit Linker

Description
Synonyms
Shipping & Delivery

Description

MC-MMAF (Maleimidocaproyl-Monomethyl Auristatin F) is a key precursor for antibody-drug conjugates (ADCs) in cancer therapy. The Mal group on the MC linker reacts with thiol groups, allowing targeted attachment to antibodies. MMAF, a synthetic antineoplastic agent, blocks tubulin polymerization, killing cancer cells.

Key Features:

MC Linker: The Mal group binds to thiol-bearing molecules, ensuring precise drug delivery.
MMAF: A potent anticancer agent that disrupts cell division.
Reagent Grade: Available for research purposes. Contact us for GMP-grade inquiries.

Applications:

ADCs: MC-MMAF enhances the delivery of cytotoxic agents to tumor cells while sparing healthy tissue.
Cancer Research: Used in developing targeted cancer therapies with high specificity.

Benefits:

Targeted Reactivity: The MC linker ensures selective binding to antibodies.
High Potency: MMAF effectively disrupts cancer cell growth at low doses.

MC-MMAF is a crucial tool in cancer therapy research, offering precise and effective solutions for ADC development. Contact us for GMP-grade options suitable for clinical use.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.

Synonyms

MC-MMAF
MAFODOTIN
McMMAF
863971-19-1
Maleimidocaproyl monomethylauristatin F
((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-
methylhexanamido)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine
MCMMA-F
mc-MMAF, mcMMAF, SGD-1269 Maleimidocaproyl monomethylauristatin FMaleimidocaproyl monomethylauristatin F
(2S)-2-[[(2R,3R)-3-[(2S)-1-[(3R,4S,5S)-4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoyl-methylamino]-3-methylbutanoyl]amino]-3-methylbutanoyl]-methylamino]-3-methoxy-5-methylheptanoyl]pyrrolidin-2-yl]-3-methoxy-2-methylpropanoyl]amino]-3-phenylpropanoic acid
(S)-2-((2R,3R)-3-((S)-1-((3R,4S,5S)-4-((S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-methylhexanamido)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoic acid
L-Phenylalanine, N-(6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl)-N-methyl-L- valyl-L-valyl-(3R,4S,5S)-3-methoxy-5-methyl-4-(methylamino)heptanoyl-(alphaR,betaR,2S)-beta- methoxy-alpha-methyl-2-pyrrolidinepropanoyl-
N-((2R,3R)-3-((2S)-1-((3R,4S,5S)-4-((N-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1- yl)hexanoyl)-N-methyl-L-valyl-L-valyl)methylamino)-3-methoxy-5- methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoyl)-L-phenylalanine
N-[(2R,3R)-2-Methyl-3-methoxy-3-[1-[(3R,4S,5S)-3-methoxy-4-[[N-[6-(2,5-dioxo-3-pyrroline-1-yl)hexanoyl]-N-methyl-L-Val-L-Val-](methyl)amino]-5-methylheptanoyl]pyrrolidine-2alpha-yl]propanoyl]-L-phenylalanine