MC (C5)-Val-Cit-OH
This product is a cleavable linker featuring a maleimidocaproyl (MC, C5) unit, a Val-Cit dipeptide, and a terminal hydroxyl group. The maleimide selectively reacts with thiols to form stable thioether bonds, while the Val-Cit sequence is cleaved by cathepsin B for intracellular release. The hydroxyl group specifically provides a handle for further modification, making this linker valuable in ADC development and drug delivery.
Key Features and Benefits
-
MC (C5) Moiety: Thiol-reactive maleimide for stable conjugation.
-
Val-Cit Linker: Protease-cleavable sequence recognized by cathepsin B.
-
Terminal Hydroxyl: Enables additional derivatization or payload attachment.
-
Cleavable Design: Supports selective intracellular release of conjugates.
-
High Purity: Produced to ≥95% purity for reproducible results.
Applications
-
Antibody–Drug Conjugates (ADCs): Provides a cleavable linker for controlled drug release.
-
Drug Delivery: Builds cathepsin B-sensitive delivery systems.
-
Probe Development: Creates cleavable probes for imaging and diagnostics.
-
Bioconjugation: Functions as a versatile intermediate for linker–payload design.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Dissolve freshly before use; avoid repeated freeze–thaw cycles.
This product integrates thiol-reactive and protease-cleavable features with a hydroxyl handle, making it an especially reliable tool for ADC research and controlled bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
