Mal-PEG4-Val-Cit-PAB-PNP
This product is a cleavable PEG4 linker with a maleimide group for thiol conjugation and a PNP ester for amine coupling. The Val–Cit dipeptide ensures cathepsin B–mediated cleavage, while the PAB spacer enables efficient payload release in ADC applications.
Key Features and Benefits:
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Maleimide Group: Selectively couples with thiols for stable cysteine conjugation.
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PNP Ester: Provides rapid, efficient amine coupling for biomolecule attachment.
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Val–Cit Dipeptide: Cleaved by proteases such as cathepsin B for selective drug release.
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PAB Spacer: Self-immolative unit ensures effective payload liberation after cleavage.
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PEG4 Spacer: Enhances solubility, flexibility, and steric accessibility.
Applications:
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ADC Linker Design: Enables site-specific drug release triggered by intracellular proteases.
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Drug Delivery: Improves solubility and targeting for therapeutic payloads.
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Bioconjugation: Combines thiol and amine reactivity with protease-sensitive cleavage.
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Synthetic Chemistry: Intermediate for multifunctional linker–payload scaffolds.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to light and moisture.
This product provides thiol- and amine-reactivity with protease-cleavable and self-immolative features, specifically making it a cornerstone linker for ADC development and targeted drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
