Mal-PEG4-Val-Cit-PAB-OH
Mal-PEG4-Val-Cit-PAB-OH is a high-purity cleavable PEG linker with a maleimide for thiol-specific conjugation, a cathepsin B–cleavable Val-Cit dipeptide, and a para-aminobenzyl (PAB) self-immolative spacer for payload release. The PEG4 spacer improves solubility, flexibility, and reduces steric hindrance, enabling efficient bioconjugation in aqueous and organic systems. This design ensures stability in circulation and controlled intracellular release, making it especially ideal for antibody–drug conjugates (ADCs), targeted therapeutics, and diagnostic probes.
Key Features and Benefits
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Maleimide Group: Enables selective thiol–maleimide conjugation.
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Val-Cit-PAB Cleavable Linker: Provides cathepsin B–triggered release inside target cells.
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PEG4 Spacer: Enhances solubility, flexibility, and accessibility of reactive groups.
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High Purity: Supplied at >95% purity for consistent, reproducible performance.
Applications
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Antibody–drug conjugates (ADCs).
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Targeted therapeutic development.
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Diagnostic probe assembly.
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Nanoparticle and surface functionalization.
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Controlled payload release systems.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve maleimide reactivity.
This product combines thiol-reactive maleimide chemistry with a cleavable linker for targeted intracellular payload release, supported by a PEG4 spacer specifically for improved solubility and flexibility.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
