Mal-PEG4-bis-PEG3-TCO
Mal-PEG4-bis-PEG3-TCO is a dual-functional PEG linker designed for precise bioconjugation and chemical biology. It features a maleimide group for specific thiol conjugation and two TCO (trans-cyclooctene) groups for fast, copper-free ligation with tetrazines via bioorthogonal inverse electron demand Diels-Alder (IEDDA) reactions. The PEG4 and bis-PEG3 linkers improve water solubility, flexibility, and reduce steric hindrance, making it suitable for a variety of biological and chemical uses.
Key Features
- Dual Functional Groups:
- Maleimide: Forms stable bonds with thiol groups (-SH).
- TCO: Reacts quickly and selectively with tetrazine compounds in bioorthogonal ligation.
- Enhanced PEG Linkers:
- Improve solubility and flexibility for diverse environments.
- Minimize steric interference, enabling efficient conjugation.
- Biocompatibility:
- Non-toxic and ideal for both in vivo and in vitro applications.
Applications
- Bioconjugation:
Attaches peptides, proteins, or nucleic acids via thiol and TCO chemistry, enabling dual-functional biomolecular systems. - Drug Delivery:
Acts as a linker in targeted drug delivery systems, improving stability and pharmacokinetics. - Nanotechnology:
Functionalizes nanoparticles, biosensors, and medical devices for bioorthogonal labeling. - Chemical Biology:
Enables rapid, copper-free labeling and crosslinking in live-cell and in vivo studies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
