Mal-(CH2)5-COOH
This product is a compact heterobifunctional linker featuring a maleimide group, a five-carbon alkyl spacer, and a terminal carboxylic acid. The maleimide reacts selectively with thiols to form stable thioether bonds, while the carboxyl group couples efficiently with primary amines or activated esters. The short alkyl chain provides minimal spacing, making this reagent especially ideal for compact, controlled bioconjugation.
Key Features and Benefits
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Maleimide Group: Reacts selectively with thiols for stable thioether bonds.
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Carboxylic Acid Group: Couples efficiently with amines to form amide linkages.
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C5 Spacer: Provides compact length and simple structure.
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Dual Reactivity: Combines thiol conjugation with amine-coupling chemistry.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Protein and Antibody Labeling: Couples thiols and amines in biomolecules.
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Bioconjugation: Links peptides, probes, or nanoparticles with orthogonal groups.
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Probe Development: Builds compact thiol- and amine-reactive probes.
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Drug Delivery: Serves as a modular linker in therapeutic design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product combines thiol-selective maleimide chemistry with amine-coupling functionality in a compact C5 scaffold, specifically offering reliability for bioconjugation and probe design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
