Mal-(CH2)3-COOH
This product is a bifunctional linker containing a maleimide group, a propyl spacer, and a terminal carboxylic acid. It specifically enables selective thiol conjugation and amide coupling, offering a compact and versatile scaffold for bioconjugation and synthesis.
Key Features and Benefits
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Maleimide Group: Couples selectively with thiols to form stable thioether bonds.
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Carboxylic Acid: Couples efficiently with amines to form stable amide linkages.
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Propyl Spacer: Provides compact spacing and hydrophobic balance.
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Dual Reactivity: Combines thiol reactivity with carboxyl conjugation.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications
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Bioconjugation: Links thiol-containing biomolecules with amine-reactive partners.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
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Drug Delivery: Provides scaffolds with thiol and amine coupling handles.
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Organic Synthesis: Serves as a versatile intermediate in linker chemistry.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates maleimide thiol-reactivity with carboxyl chemistry in a compact propyl scaffold, specifically providing dual functionality for conjugation and synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
