Mal-amido-PEG7-acid
Mal-amido-PEG7-acid is a bifunctional PEG7 linker with a maleimide for thiol conjugation and a terminal acid for amide coupling. This dual reactivity makes it an especially versatile tool for bioconjugation, ADC development, and drug delivery applications.
Key Features and Benefits:
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Maleimide Group: Enables site-specific thiol conjugation for cysteine residues.
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Carboxylic Acid Group: Couples efficiently with amines for stable amide bonds.
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PEG7 Spacer: Provides hydrophilicity, flexibility, and reduced steric hindrance.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
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Dual Reactivity: Supports orthogonal conjugation strategies.
Applications:
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Bioconjugation: Crosslink proteins, peptides, and biomolecules via thiol and amine groups.
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Antibody-Drug Conjugates (ADCs): Useful in linker-payload design for targeted therapeutics.
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Drug Delivery Systems: Enhances solubility and pharmacokinetics of payloads.
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Surface Functionalization: Functionalizes nanoparticles, polymers, or biosensors.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain reactivity.
This product provides balanced solubility and spacing with dual-reactive functional groups, making it an especially effective linker for controlled conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
