Mal-amido-PEG3-NHS Acetate (CAS: 2101206-45-3)
A heterobifunctional PEG linker with a maleimide group and an NHS ester, connected by a three-unit PEG spacer. It facilitates efficient conjugation between thiol and amine groups, making it useful in bioconjugation and drug development.
Features:
- Molecular Formula: C₁₉H₂₅N₃O₁₀
- Molecular Weight: 455.42 g/mol
- Functional Groups:
- Maleimide (-C=CH-CO-)
- NHS Ester (-CO-NHS)
- PEG Spacer Length: 3 ethylene glycol units
- Purity: ≥95%
- Physical State: Colorless to off-white liquid
Applications:
- Antibody-Drug Conjugates (ADCs):
- Acts as a stable, non-cleavable linker for attaching cytotoxic drugs to antibodies in targeted cancer therapies.
- Protein and Peptide Modification:
- Enables site-specific conjugation of proteins or peptides through thiol and amine groups, aiding in therapeutic and diagnostic development.
- Bioconjugation:
- Reacts with thiol and primary amine groups, facilitating the conjugation of various biomolecules.
- Drug Delivery Systems:
- Enhances solubility and biocompatibility, making it suitable for drug delivery platforms with improved pharmacokinetics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
