Mal-amido-PEG2-Val-Cit-PAB-PNP
This product is a cleavable PEG2 linker featuring a maleimide for thiol conjugation and a PNP ester for amine coupling. The Val–Cit dipeptide ensures cathepsin B–mediated cleavage, while the PAB spacer enables efficient payload release in ADC applications.
Key Features and Benefits:
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Maleimide Group: Couples selectively to thiols for stable cysteine conjugation.
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PNP Ester: Reacts rapidly with amines for efficient linker–payload assembly.
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Val–Cit Dipeptide: Cleaved by cathepsin B for targeted intracellular release.
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PAB Spacer: Self-immolative unit ensures complete and timely drug liberation.
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PEG2 Spacer: Provides hydrophilicity and compact flexibility.
Applications:
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ADC Linker Design: Core reagent for antibody–drug conjugates with controlled release.
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Drug Delivery: Enhances solubility and stability of conjugates.
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Bioconjugation: Combines thiol- and amine-reactive handles with enzymatic cleavage.
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Probe Development: Useful in designing targeted, cleavable imaging or therapeutic probes.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to light or moisture.
This product integrates thiol and amine reactivity with protease-cleavable and self-immolative features, making it a cornerstone linker specifically for ADC development and targeted bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
