Mal-amido-PEG2-Val-Cit-PAB-OH
This product is a cleavable linker containing a maleimide for thiol conjugation, a PEG2 spacer, and a Val-Cit-PAB self-immolative motif. This design enables cysteine-selective attachment and controlled payload release, making it especially effective for ADC development, drug delivery, and targeted bioconjugation.
Key Features and Benefits:
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Maleimide Group: Selectively reacts with thiols to form stable thioether bonds.
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PEG2 Spacer: Enhances solubility and reduces steric hindrance.
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Val-Cit-PAB Motif: Provides protease-cleavable and self-immolative release.
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Dual Functionality: Combines stable conjugation with controlled payload release.
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High Purity: Ensures reproducibility for sensitive therapeutic applications.
Applications:
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ADC Development: Serves as a widely used linker for antibody–drug conjugates.
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Drug Delivery: Enables tumor-targeted release via protease cleavage.
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Bioconjugation: Couples thiol-containing biomolecules with cleavable drug scaffolds.
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Probe Design: Builds enzyme-activated probes for imaging and diagnostics.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid hydrolysis of maleimide.
This product integrates thiol-selective conjugation with protease-cleavable drug release in a PEG2 scaffold, specifically offering a proven design for ADCs and advanced therapeutic strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
