Mal-amido-PEG2-TFP ester is PEG derivative containing a maleimide and TFP ester end group. Maleimide groups readily reacts with thiols between pH 6.5 and 7.5 to form S-C bond. The TFP ester can be reacted with primary amine groups and is also less susceptible to undergo hydrolysis compared to NHS ester. The PEG spacer increase the solubility of the compound in aqueous media.
Mal-amido-PEG2-TFP ester is a type of polyethylene glycol (PEG) derivative that contains two methyl groups, an amide group, and a tert-butyl fluorophosphonate group. It is used in the synthesis of peptide-based drugs, such as peptide nucleic acids, and as a linker molecule to attach drugs to targeting molecules, such as antibodies. The mal-amido-PEG2-TFP ester is also used to stabilize peptide sequences and to improve solubility and bioavailability of peptide drugs.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
