Mal-amido-PEG2-TFP ester
This bifunctional PEG2 reagent has a maleimide for thiol coupling and a TFP ester for amine coupling, enabling stable thioether and amide linkages in bioconjugation.
Key Features and Benefits:
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Maleimide Group: Provides thiol-selective reactivity for cysteine-containing biomolecules.
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TFP Ester: More hydrolytically stable than NHS esters, ensuring efficient amine coupling.
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PEG2 Spacer: Improves solubility, flexibility, and reduces steric hindrance.
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High Purity: Delivers reproducible results in protein and peptide conjugation workflows.
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Versatile Chemistry: Suitable for aqueous and organic reactions.
Applications:
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Bioconjugation: Dual-reactive linker for thiol-amine crosslinking.
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Antibody and Protein Labeling: Enables site-specific and stable conjugates.
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Drug Delivery Systems: Used as a spacer-linker for ADC and targeted delivery strategies.
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Surface Modification: Functionalize nanoparticles, polymers, or biomaterials.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve maleimide and ester reactivity.
This product combines thiol and amine reactivity with a hydrophilic PEG spacer, making it an especially effective crosslinker for advanced conjugation and drug delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
