m-PEG5-Ms
This product is a monomethyl-capped polyethylene glycol derivative terminated with a mesylate (Ms) group. The PEG5 spacer provides hydrophilicity and flexibility, while the mesylate acts as an excellent leaving group, enabling nucleophilic substitution to generate diverse PEG-functionalized molecules.
Key Features and Benefits
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Mesylate Group (Ms): Highly reactive leaving group for substitution with amines, thiols, or alkoxides.
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PEG5 Spacer: Improves solubility and reduces steric hindrance in conjugation workflows.
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Monomethyl-Capped: Prevents crosslinking and ensures single functional reactivity.
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Synthetic Versatility: Useful intermediate for preparing PEG-amines, PEG-thiols, and other PEG derivatives.
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High Purity: Produced to ≥95% purity for reliable synthetic applications.
Applications
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PEG Derivatization: Converts to functionalized PEGs through nucleophilic substitution.
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Bioconjugation: Precursor for PEG linkers in drug delivery and probe development.
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Surface Modification: Functionalizes materials and nanoparticles for improved biocompatibility.
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Organic Synthesis: Versatile starting material for advanced PEGylated intermediates.
Storage and Handling
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Storage: Store at –20 °C in a dry, sealed container away from light and moisture.
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Handling: Use under inert conditions when possible; dissolve freshly before reaction.
This product provides a mesylate-functionalized PEG5 backbone, offering an especially versatile intermediate for nucleophilic substitution and PEG-based conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
