m-PEG5-acid
This product is a monofunctional PEG derivative containing a five-unit polyethylene glycol chain capped with a methyl group and terminated with a carboxylic acid. The acid group couples efficiently with amines or hydroxyls to form stable amide or ester linkages, while the PEG5 spacer provides solubility and flexibility. Its compact design makes it an especially versatile intermediate for PEGylation, surface modification, and bioconjugation.
Key Features and Benefits
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Carboxylic Acid Group: Reacts readily with amines or alcohols for conjugation.
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PEG5 Spacer: Provides hydrophilicity and moderate chain flexibility.
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Monomethyl Capping: Ensures single-point reactivity, avoiding crosslinking.
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Versatile Intermediate: Suitable for conversion to diverse PEG derivatives.
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High Purity: Produced to ≥95% purity for reproducible performance.
Applications
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Bioconjugation: Couples with proteins, peptides, or nanoparticles via amide/ester chemistry.
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Surface Modification: Functionalizes polymers, nanoparticles, and biomaterials.
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PEGylation: Enhances solubility and stability of therapeutic molecules.
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Organic Synthesis: Serves as a building block for advanced PEG linkers.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product combines a reactive carboxyl group with a hydrophilic PEG5 chain, specifically offering a reliable tool for PEGylation and versatile conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
