m-PEG3-Norbornene
m-PEG3-Norbornene is a high-purity PEG linker with a norbornene group for rapid, catalyst-free inverse electron-demand Diels–Alder (IEDDA) click chemistry and a monofunctional PEG3 spacer for improved solubility and flexibility. Its compact, hydrophilic design specifically enables efficient bioconjugation in aqueous and organic systems for drug delivery, diagnostics, and advanced materials.
Key Features and Benefits
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Norbornene Functional Group: Reacts rapidly with tetrazines in bioorthogonal IEDDA click chemistry.
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PEG3 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Monofunctional Design: Allows single-point functionalization for precise control.
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High Purity: Supplied at >95% purity for reproducible, high-yield performance.
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Versatile Reactivity: Suitable for aqueous and organic conjugation systems.
Applications
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Bioorthogonal Labeling: Attach norbornene handles for tetrazine-based click chemistry.
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Protein and Peptide Modification: Enable site-specific functionalization.
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Nanoparticle Functionalization: Add norbornene groups for targeted surface modification.
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Drug Delivery Systems: Build linkers for precise payload attachment and release.
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Diagnostic Probe Development: Create multifunctional probes for imaging and sensing.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve reactivity.
m-PEG3-Norbornene provides a norbornene click handle in a hydrophilic PEG3 framework, enabling especially rapid, catalyst-free conjugation with tetrazines for precision linker design in therapeutics, diagnostics, and materials science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
