m-PEG1-acid
This product is a compact PEG linker composed of a monomethyl-terminated PEG1 chain and a terminal carboxylic acid. The carboxyl group couples efficiently with primary amines or activated esters to form stable amide bonds, while the short PEG1 spacer improves solubility with minimal added length. Its small, hydrophilic structure makes it especially ideal for compact PEGylation and bioconjugation strategies.
Key Features and Benefits
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Carboxylic Acid Group: Couples efficiently with amines for amide bond formation.
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PEG1 Spacer: Provides hydrophilicity and flexibility with minimal bulk.
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Monomethyl Capping: Prevents crosslinking by ensuring single reactive functionality.
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Compact Design: Adds solubility without significant steric hindrance.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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PEGylation: Introduces short PEG units to biomolecules or surfaces.
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Bioconjugation: Couples proteins, peptides, or probes via acid/amine chemistry.
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Probe Development: Builds compact PEGylated intermediates for imaging and diagnostics.
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Drug Delivery: Enhances solubility and stability of therapeutic molecules.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Prepare fresh solutions; avoid repeated freeze–thaw cycles.
This product combines PEG solubility with a reactive carboxyl group in a minimal framework, specifically offering an efficient tool for compact conjugation and PEGylation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
