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I-BET 762

Catalog #: AP14250
Name: I-BET 762
Chemical Formula: C22H22ClN5O2
Molecular Weight: 423.90
CAS: 1260907-17-2
Purity: ≥95%
Availability: In Stock

I-BET 762

$230.00 – $950.00

UnitPriceQuantity
10 mg$230
25 mg$460
50 mg$950

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SKU: AP14250 Category:
Description

I-BET-762 CAS:1260907-17-2 is a benzodiazepine, cell-permeable BET protein inhibitor that binds to the tandem bromodomains (bromodomain and extra terminal domain) of BET. I-BET-762 binds to BRD2 (1-473), BRD3 (1-434) and BRD4 (1-477) with high affinity (ITC Kd = 61.3, 50.5 and 55.2 nM, respectively) and competes effectively against BRD2/3 /4 binds the tetraacetylated H4 peptide (IC50 = 32.5, 42, 4 and 36.1 nM, respectively) and has little affinity for the other 5 bromodomain-containing proteins (ATAD2, BAZ2B, CREBBP, PCAF, SP140) . I-BET-762 has been reported to downregulate the expression of LPS-induced genes, resulting in decreased LPS-induced expression of cytokines and chemokines.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.

Synonyms
  • 1260907-17-2
  • I-BET-762
  • I-BET762
  • I-BET 762
  • (S)-2-(6-(4-Chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide
  • 2-[(4s)-6-(4-Chlorophenyl)-8-Methoxy-1-Methyl-4h-[1,2,4]triazolo[4,3-A][1,4]benzodiazepin-4-Yl]-N-Ethylacetamide
  • 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-4-acetamide, 6-(4-chlorophenyl)-N-ethyl-8-methoxy-1-methyl-, (4S)-
  • EAM iBET (S)-2-(6-(4-Chlorophenyl)-8-methoxy-1-methyl-4H-benzo-[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide
  • (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide
  • 2-((4S)-6-(4-Chlorophenyl)-8-methoxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide
  • 2-[(4S)-6-(4-Chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
Shipping & Delivery
Ships within: 24 hours
Storage condition: -20 ° C
Shipping: Ambient Temperature

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