I-BET-762 CAS:1260907-17-2 is a benzodiazepine, cell-permeable BET protein inhibitor that binds to the tandem bromodomains (bromodomain and extra terminal domain) of BET. I-BET-762 binds to BRD2 (1-473), BRD3 (1-434) and BRD4 (1-477) with high affinity (ITC Kd = 61.3, 50.5 and 55.2 nM, respectively) and competes effectively against BRD2/3 /4 binds the tetraacetylated H4 peptide (IC50 = 32.5, 42, 4 and 36.1 nM, respectively) and has little affinity for the other 5 bromodomain-containing proteins (ATAD2, BAZ2B, CREBBP, PCAF, SP140) . I-BET-762 has been reported to downregulate the expression of LPS-induced genes, resulting in decreased LPS-induced expression of cytokines and chemokines.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
![l-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-lHpyrazolo [3,4-d]pyrimidin-l-yl]-l-piperidinyl]-2-propyn-l-one](https://e1752fbe.rocketcdn.me/wp-content/uploads/AP14272-CAS-936563-91-6-1-e1686054563587.png)
![N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine](https://e1752fbe.rocketcdn.me/wp-content/uploads/AP14270-CAS-231278-20-9-1-e1686064939791.png)
