HO-PEG11-t-butyl ester
This product is a heterobifunctional PEG linker featuring a terminal hydroxyl group and an acid-labile t-butyl ester. The PEG11 spacer specifically enhances solubility, flexibility, and long-chain spacing, making it highly effective for orthogonal conjugation, drug delivery, and advanced probe design.
Key Features and Benefits:
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Hydroxyl Group: Provides a modifiable handle for derivatization.
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t-Butyl Ester: Acid-labile protection allows controlled deprotection.
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PEG11 Spacer: Enhances solubility, hydrophilicity, and steric flexibility.
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Orthogonal Reactivity: Supports multi-step, controlled conjugation strategies.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications:
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Bioconjugation: Enables orthogonal design of PEGylated biomolecules.
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Drug Delivery: Supports PEGylated scaffolds with controlled release features.
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Probe Development: Builds multifunctional imaging and diagnostic probes.
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Material Science: Functionalizes polymers, nanoparticles, and advanced surfaces.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid premature t-butyl ester cleavage.
This product combines a hydroxyl handle with a protected ester in a PEG11 scaffold, specifically offering solubility, flexibility, and synthetic versatility for bioconjugation and advanced applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
