HO-PEG7-t-butyl ester
HO-PEG7-t-butyl ester is a high-purity PEG reagent with a terminal hydroxyl group for versatile derivatization and a tert-butyl ester–protected carboxyl for selective deprotection under mild acidic conditions. The PEG7 spacer improves solubility, flexibility, and reduces steric hindrance, supporting especially efficient conjugation in both aqueous and organic systems.
Key Features and Benefits
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Hydroxyl Group – Serves as a versatile handle for further functionalization.
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t-Butyl Ester Protection – Acid-labile protection allows orthogonal conjugation strategies.
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PEG7 Spacer – Enhances aqueous solubility, molecular flexibility, and accessibility of reactive groups.
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Orthogonal Reactivity – Supports sequential modification without cross-reactivity.
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High Purity – Supplied at >95% purity for reliable and reproducible performance.
Applications
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Stepwise functionalization and linker synthesis
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Polymer and surface modification
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Prodrug and drug delivery system design
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Multifunctional bioconjugate development
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactivity
This product combines a hydroxyl group for derivatization with a t-butyl–protected carboxyl, separated by a PEG7 spacer for solubility and flexibility, specifically enabling orthogonal conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
