HO-PEG10-t-butyl ester
HO-PEG10-t-butyl ester is a high-purity PEG10 linker with a terminal hydroxyl group and an acid-labile tert-butyl ester. The hydroxyl allows versatile coupling, while the tert-butyl ester enables controlled deprotection under mild acidic conditions. The PEG10 spacer enhances solubility, flexibility, and reduces steric hindrance, making it especially ideal for chemical synthesis, bioconjugation, and material development.
Key Features and Benefits
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Dual Functional Groups: Hydroxyl group for versatile conjugation and tert-butyl ester for acid-labile protection.
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PEG10 Spacer: Improves hydrophilicity, reduces aggregation, and provides molecular flexibility.
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High Purity: Supplied at >95% purity for consistent performance in research and manufacturing.
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Controlled Deprotection: t-Butyl ester allows selective release of the carboxylic acid under mild acidic conditions.
Applications
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Precursor for the synthesis of functionalized PEG derivatives.
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Building block for multi-step bioconjugation strategies.
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Surface modification and polymer chemistry.
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Linker design in drug delivery and diagnostic probes.
Storage and Handling
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Storage: Store at –20 °C in a dry, dark environment.
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Handling: Avoid exposure to moisture and light. Use anhydrous solvents during reactions.
This product is a bifunctional PEG10 linker with a hydroxyl group for versatile coupling and a tert-butyl ester for controlled acid-labile deprotection, offering especially excellent solubility and flexibility for chemical synthesis and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
