Folate-amido-C2-amine-endo-BCN
Folate-amido-C2-amine-endo-BCN is a high-purity heterobifunctional linker that combines folic acid for receptor-targeted delivery with an endo-BCN (bicyclo[6.1.0]nonyne) group for rapid, catalyst-free strain-promoted azide–alkyne cycloaddition (SPAAC). The short C2 alkyl spacer with a terminal amine enables especially versatile coupling to carboxylic acids or NHS esters. This design specifically allows precise site-specific conjugation of folate to azide-containing biomolecules, nanoparticles, or therapeutic payloads for targeted delivery to folate receptor–expressing cells.
Key Features and Benefits
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Folate Moiety: Enables high-affinity targeting of folate receptor–positive cells, enhancing selective uptake.
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Endo-BCN Group: Performs rapid SPAAC click chemistry with azides under physiological conditions, without metal catalysts.
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C2 Amine Spacer: Provides a short, flexible handle for coupling to carboxylic acids, NHS esters, or activated carbonates.
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Targeted Bioconjugation: Combines receptor-mediated uptake with bioorthogonal reactivity.
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High Purity: Supplied at >95% purity for reproducible results in sensitive applications.
Applications
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Targeted Drug Delivery: Conjugate drugs, toxins, or imaging agents to folate for receptor-specific delivery.
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Nanoparticle Functionalization: Add folate and BCN handles to nanoparticle surfaces for targeted binding.
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Bioconjugate Assembly: Link azide-functionalized biomolecules via catalyst-free SPAAC.
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Diagnostic Imaging: Create folate-targeted imaging probes for PET, MRI, or fluorescence detection.
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Theranostics: Combine therapeutic and diagnostic capabilities in a single conjugate.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve reactivity of BCN and amine groups.
Folate-amido-C2-amine-endo-BCN combines folate receptor targeting with BCN click chemistry for especially rapid, catalyst-free conjugation to azide-functionalized molecules, enabling precision drug delivery and diagnostic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.