Fmoc-Val-Cit-OH (CAS: 159858-21-6) plays an essential role in peptide synthesis and drug development. Its Fmoc-protected valine-citrulline sequence provides stability and precise reactivity. Because of these properties, researchers frequently use it in linker-based drug delivery and targeted therapies.
The valine-citrulline bond responds specifically to cathepsin enzymes, allowing controlled drug release. This selectivity improves therapeutic effectiveness while reducing unwanted side effects. As a result, Fmoc-Val-Cit-OH remains a trusted choice in pharmaceutical and biomedical research.
Key Features
- Fmoc-Protected Dipeptide – Enhances stability and ensures controlled reactivity.
- Cleavable Linker – Plays a crucial role in ADCs and enzyme-sensitive drug release.
- Highly Selective – Enables drug activation only at the target site.
- Broad Applications – Supports peptide synthesis, targeted therapies, and biomedical research.
- Reliable & Effective – Delivers consistent and reproducible results.
Applications
- Peptide Synthesis – Provides a stable building block.
- Antibody-Drug Conjugates (ADCs) – Functions as a precise linker in targeted therapies.
- Enzyme-Cleavable Linkers – Ensures controlled drug release.
- Targeted Drug Delivery – Contributes to the development of innovative treatments.
- Biomedical Research – Helps scientists study protease-sensitive drug activation.
Conclusion
To sum up, Fmoc-Val-Cit-OH offers a reliable solution for peptide synthesis and targeted drug delivery. Its Fmoc-protected structure ensures stability, while its enzyme-cleavable properties allow precise drug activation. Because of its efficiency and versatility, researchers continue to use it in pharmaceutical and biomedical applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
