Fmoc-NMe-PEG3-acid
This product is a heterobifunctional PEG linker containing an Fmoc-protected N-methyl amine, a PEG3 spacer, and a terminal carboxylic acid. It specifically enables orthogonal protection, amide coupling, and conjugation, offering solubility, compact length, and controlled reactivity.
Key Features and Benefits
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Fmoc-Protected N-Methyl Amine: Provides selective deprotection for orthogonal conjugation strategies.
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Carboxylic Acid: Couples efficiently with primary amines to form stable amide bonds.
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PEG3 Spacer: Enhances solubility and provides compact flexibility.
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Controlled Reactivity: Combines N-methyl amine protection with active carboxyl chemistry.
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High Purity: Ensures reproducibility in synthesis and bioconjugation workflows.
Applications
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Bioconjugation: Links biomolecules through orthogonal amine and carboxyl reactivity.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
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Drug Delivery: Provides PEG scaffolds with solubility and staged reactivity.
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Organic Synthesis: Serves as a versatile intermediate in modular linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid premature hydrolysis or Fmoc removal.
This product integrates an Fmoc-protected N-methyl amine with a carboxyl group in a PEG3 scaffold, specifically offering solubility, orthogonal control, and versatile conjugation capability.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
