Fmoc-NH-PEG12-Acid (Fmoc-NH-PEG12-COOH), CAS number 756526-01-9, is a flexible PEG linker with an Fmoc-protected amine on one end and a carboxyl group on the other.
Key Features:
- Structure: It features a 12-unit PEG chain with an Fmoc group protecting the amine and a reactive carboxyl group, creating a stable, adaptable spacer.
- Reactivity:
- You can easily remove the Fmoc group under mild conditions, exposing the free amine for further reactions.
- The carboxyl group reacts with amines or alcohols, forming amide or ester bonds for efficient conjugation.
- Applications:
- Peptide Synthesis: It works well in solid-phase peptide synthesis (SPPS) due to its Fmoc protection.
- Bioconjugation: The linker connects peptides, proteins, or biomolecules with stability and flexibility.
- Drug Delivery: It improves solubility and circulation time in drug conjugates.
- Surface Modification: It is perfect for functionalizing surfaces in biosensors and nanotechnology.
- Solubility: The PEG12 chain enhances water solubility and biocompatibility, minimizing non-specific interactions in biological systems.
Summary:
Fmoc-NH-PEG12-Acid (Fmoc-NH-PEG12-COOH) is a versatile PEG linker. It supports peptide synthesis, bioconjugation, and drug delivery by providing easy Fmoc removal, high solubility, and biocompatibility, making it valuable in both research and therapeutic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
