Fmoc-NH-PEG-Mal, MW 5K is a polymer that has gained significant attention in the field of pharmaceutical research and development due to its unique chemical properties. This polymer is composed of a polyethylene glycol (PEG) chain with an N-terminal fluorenylmethoxycarbonyl (Fmoc) protecting group, a malimide functional group (Mal), and a molecular weight of 5K.
The Fmoc group serves as a protecting agent for the amino group on the PEG chain, enabling the selective modification of the Mal group without interfering with the PEG backbone. The Mal group is known for its ability to react specifically with thiol-containing molecules, such as cysteine residues on proteins, forming stable thioether bonds.
The Fmoc-NH-PEG-Mal polymer has a wide range of applications in pharmaceutical research and development. It is commonly used for the conjugation of therapeutic proteins and peptides to PEG, creating biologically active macromolecules with improved pharmacokinetic properties. The Mal group allows for site-specific modification of these conjugates, enabling the controlled release of therapeutic agents and targeting specific tissues or cells.
Furthermore, the Fmoc-NH-PEG-Mal polymer can also be utilized in the design of drug delivery systems, such as nanoparticles and liposomes. The Mal group allows for the attachment of targeting ligands or imaging agents to the surface of these systems, increasing their specificity and efficacy.
Fmoc-NH-PEG-Mal, MW 5K is a versatile and valuable tool in pharmaceutical research and development. Its unique functional groups enable the site-specific modification and targeting of therapeutic agents and the design of innovative drug delivery systems, leading to improved therapeutic outcomes and reduced
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
