Fmoc-NH-PEG-Mal, MW 1K is a chemical compound that belongs to the class of polyethylene glycol (PEG) derivatives. This polymer contains multiple functional groups, including an Fmoc-protected amine group, a maleimide group, and a PEG chain with a molecular weight of 1 kilodalton (kDa). These functional groups make Fmoc-NH-PEG-Mal a valuable tool in the field of pharmaceutical research and development.
The Fmoc-protected amine group is commonly used for peptide synthesis, as it can be easily deprotected and coupled with other amino acids to form peptides. The maleimide group, on the other hand, is known for its ability to react with thiol groups, making Fmoc-NH-PEG-Mal a useful tool in the development of thiol-reactive drug delivery systems. The PEG chain provides biocompatibility and improves solubility, making this polymer an attractive candidate for use in pharmaceutical applications.
Fmoc-NH-PEG-Mal has been extensively used in the development of targeted drug delivery systems. For example, it can be used to conjugate therapeutic agents, such as peptides or small molecules, to targeting moieties, such as antibodies or aptamers, via the maleimide group. The resulting conjugates can then be delivered specifically to cells or tissues expressing the target molecule, leading to improved therapeutic efficacy and reduced side effects.
In addition to drug delivery systems, Fmoc-NH-PEG-Mal has also been used in the development of imaging agents and biosensors. The maleimide group can be used to immobilize fluorescent dyes or other imaging agents onto PEG chains, allowing for targeted imaging of specific cells or tissues. The Fmoc-protected amine group can also be used to immobilize biomolecules onto surfaces, enabling the development of biosensors for the detection of specific molecules or biomarkers.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
