Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester), CAS Number 479081-06-6, is a specialized bioconjugation compound used in radiolabeling and peptide synthesis.
Overview
- Full Name: Fmoc-Lysine-mono-amide-DOTA-tris(tert-butyl ester).
- CAS Number: 479081-06-6.
- Chemical Formula: C48H71N5O10.
- Molecular Weight: 882.13 g/mol.
Key Applications
- Bioconjugation: The Fmoc-protected lysine allows for incorporation into peptide synthesis, while the amide-DOTA enables metal chelation.
- Radiolabeling: DOTA is a strong chelator for metal ions, such as Gallium-68 for PET imaging or Lutetium-177 for radiotherapy.
- Peptide Synthesis: Often used in solid-phase peptide synthesis (SPPS), facilitating the creation of targeted imaging agents.
Properties
- Fmoc Protection: Protects the lysine’s amine group during peptide synthesis, allowing controlled modifications.
- tert-Butyl Ester Protection: Keeps DOTA’s carboxyl groups stable during synthesis, ensuring proper functionality for chelation.
- Chelating Strength: DOTA forms strong, stable complexes with metal ions, supporting reliable radiolabeling.
Handling and Storage
- Storage: Store in a cool, dry environment away from light to maintain stability.
- Handling: Use protective gear to prevent undesired reactions during synthesis.
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