Fmoc-Ala-Ala-Asn-PAB-PNP (CAS: 1834516-06-1) is a cleavable peptide linker used in antibody-drug conjugates (ADCs) and peptide-based prodrugs. It consists of an Ala-Ala-Asn amino acid sequence, a para-aminobenzyl (PAB) spacer, and a p-nitrophenyl (PNP) carbonate group, which enhances its conjugation capabilities with amine-containing payloads.
Key Features:
- Cleavable Linker: The Ala-Ala-Asn sequence allows enzyme-specific cleavage, enabling controlled drug release.
- PAB Spacer: Stabilizes the linker and ensures efficient drug release upon cleavage.
- PNP Group: Acts as a leaving group, aiding in the conjugation to amine-bearing payloads.
Applications:
- Antibody-Drug Conjugates (ADCs): Links antibodies to cytotoxic drugs for targeted delivery to cancer cells.
- Peptide-Based Prodrugs: Enables inactive prodrugs to be activated by specific enzymes at the target site, enhancing efficacy and reducing side effects.
Storage and Handling:
- Storage: Store at -20°C in a dry, dark environment.
- Handling: Use an inert atmosphere to preserve stability and prevent degradation.
Ala-Ala-Asn-PAB is a valuable component in targeted drug delivery systems, providing a reliable mechanism for enzyme-triggered therapeutic release.
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