endo-BCN-PEG4 acid
This product is a strained bicyclononyne (BCN) derivative with a PEG4 spacer and terminal carboxylic acid. It enables fast, copper-free click chemistry with azides while providing solubility and functionalization potential for bioconjugation and material science applications.
Key Features and Benefits
-
BCN Group: Supports rapid strain-promoted azide–alkyne cycloaddition (SPAAC) without copper.
-
Carboxylic Acid: Couples efficiently with amines to form stable amide bonds.
-
PEG4 Spacer: Enhances solubility and reduces steric hindrance.
-
Bioorthogonal Reactivity: Compatible with living systems and sensitive biomolecules.
-
High Purity: Provides reproducible results in demanding applications.
Applications
-
Bioconjugation: Attaches azide-labeled biomolecules via copper-free click chemistry.
-
Drug Delivery: Builds PEGylated scaffolds with dual functional handles.
-
Probe Development: Creates bioorthogonal probes for imaging and diagnostics.
-
Material Science: Functionalizes polymers and nanostructures with BCN–azide reactivity.
Storage and Handling
-
Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to moisture.
This product combines strain-promoted click reactivity with carboxyl coupling in a PEG4 scaffold, specifically offering a versatile and bioorthogonal tool for advanced synthesis and bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
