endo-BCN-NHS Carbonate
This product is a heterobifunctional linker featuring an endo-bicyclononyne (BCN) group and an NHS carbonate. The BCN enables rapid, copper-free SPAAC click chemistry with azides, while the NHS carbonate reacts efficiently with primary amines to form stable carbamate linkages. This combination provides orthogonal reactivity, making the reagent especially useful for bioconjugation, probe development, and drug delivery.
Key Features and Benefits
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BCN Group: Performs ultrafast, copper-free SPAAC click chemistry with azides.
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NHS Carbonate: Couples with amines to form stable carbamate bonds.
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Orthogonal Reactivity: Supports dual functionalization strategies.
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Compact Design: Minimizes steric hindrance while maintaining solubility.
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High Purity: Produced to ≥95% purity for reproducible results.
Applications
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Bioconjugation: Links azide- and amine-modified biomolecules.
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Protein and Antibody Labeling: Provides dual handles for multifunctional modification.
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Probe Development: Builds dual-reactive probes for imaging and diagnostics.
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Drug Delivery: Serves as a modular linker in targeted therapeutics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Use freshly prepared solutions; NHS groups are moisture-sensitive.
This product combines SPAAC reactivity and amine coupling in a compact scaffold, making it an especially versatile tool for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.