(E/Z)-4-Hydroxytamoxifen (4-OHT): Essential for Genetic Research
What is (E/Z)-4-Hydroxytamoxifen?
(E/Z)-4-Hydroxytamoxifen (4-OHT), also known as cis/trans-4-hydroxytamoxifen or afimoxifene, is an active metabolite of tamoxifen and a selective estrogen receptor modulator (SERM). It’s a critical tool in genetic research and manipulation.
Key Uses
- Cre-LoxP System: Activates CreER/CreERT2 recombinase for precise, tissue-specific gene modifications, including gene deletions.
- TRAP/TRAP2 Systems: Facilitates targeted genetic access to neuronal activity.
- CRISPR/Cas9 Editing: Activates inactivated Cas9 nuclease for accurate genome editing.
Additional Benefits
- Antioxidant Properties: Inhibits lipid peroxidation and scavenges peroxyl radicals, useful for studying oxidative stress.
Why Choose (E/Z)-4-Hydroxytamoxifen?
- Targeted Genetic Control: Perfect for inducible genetic manipulation and research.
- Versatile Applications: Useful in advanced genetic systems and oxidative stress studies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
