DSPE-PEG4-DBCO
This product is an amphiphilic conjugate that combines a DSPE lipid anchor, a short PEG4 spacer, and a terminal dibenzocyclooctyne (DBCO) group. The DSPE moiety stably embeds into lipid bilayers, micelles, and liposomes, while the PEG4 chain enhances solubility and reduces aggregation. The DBCO enables ultrafast, copper-free SPAAC click chemistry with azides, making this reagent especially effective for nanomedicine, drug delivery, and surface functionalization.
Key Features and Benefits
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DSPE Lipid Anchor: Provides stable insertion into liposomes, micelles, and membranes.
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PEG4 Spacer: Improves solubility and minimizes steric hindrance.
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DBCO Group: Performs rapid, copper-free SPAAC click chemistry with azides.
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Amphiphilic Design: Bridges lipid anchoring with bioorthogonal reactivity.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Drug Delivery: Functionalizes liposomes and nanoparticles for targeted therapies.
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Nanotechnology: Adds clickable groups to micelles and lipid assemblies.
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Bioconjugation: Couples azide-modified biomolecules to lipid-based systems.
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Probe Development: Creates functional liposome–probe conjugates for imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product combines stable lipid anchoring, short PEG solubility, and copper-free click reactivity, offering an especially reliable tool for advanced lipid–biomolecule conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.