DOTA-PEG5-C6-DBCO
This product is a multifunctional chelator–linker containing a DOTA moiety, a PEG5 spacer, a C6 alkyl chain, and a dibenzocyclooctyne (DBCO) group. The DOTA chelator enables stable coordination of radiometals for imaging or therapeutic applications. Meanwhile, the DBCO group provides copper-free click chemistry with azides. The PEG5 spacer and C6 linker specifically enhance solubility, flexibility, and accessibility during conjugation.
Key Features and Benefits
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DOTA Chelator: Forms stable complexes with radiometals such as ^64Cu, ^68Ga, ^177Lu, and others.
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DBCO Group: Enables strain-promoted azide–alkyne cycloaddition (SPAAC) without requiring copper catalysts.
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PEG5 Spacer: Improves solubility, reduces steric hindrance, and enhances conjugation efficiency.
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C6 Linker: Provides additional flexibility and spacing between functional domains.
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High Purity: Produced to ≥95% purity for consistent radiolabeling and bioconjugation performance.
Applications
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Radiolabeling: Coordinates diagnostic and therapeutic radionuclides via DOTA for imaging and radiotherapy.
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Bioconjugation: Couples azide-modified biomolecules, antibodies, or nanoparticles using DBCO click chemistry.
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Probe Development: Builds radiolabeled probes for PET, SPECT, or theranostic studies.
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Drug Delivery: Integrates targeting ligands with radiometals for advanced therapeutic delivery systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light-protected container.
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Handling: Use under inert atmosphere when possible; dissolve freshly in aqueous buffer or dry solvent before use.
This product integrates a versatile DOTA chelator, a reactive DBCO group, and solubilizing PEG5/C6 spacers, specifically offering a powerful platform for radiolabeling, click chemistry, and advanced bioconjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
