DOTA-PEG5-azide
This product is a PEG-based chelator linker containing a DOTA macrocycle, a PEG5 spacer, and a terminal azide. It enables efficient metal chelation for radiolabeling and bioorthogonal conjugation through copper-catalyzed or strain-promoted click chemistry, making it especially versatile for imaging and therapeutic applications.
Key Features and Benefits
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DOTA Core: Robust macrocyclic chelator for radiometals such as Ga³⁺, Cu²⁺, and Lu³⁺.
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Azide Group: Reacts with alkynes via CuAAC or SPAAC click chemistry.
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PEG5 Spacer: Enhances solubility and reduces steric hindrance.
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Dual Functionality: Combines metal chelation with bioorthogonal conjugation.
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High Purity: Ensures reproducibility in radiochemistry and bioconjugation workflows.
Applications
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Radiolabeling: Chelates radiometals for PET/SPECT imaging and therapeutic applications.
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Bioconjugation: Couples to alkyne-modified biomolecules via click chemistry.
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Probe Development: Builds multifunctional imaging probes with metal-chelating capability.
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Drug Delivery: Provides PEGylated scaffolds with radiolabeling and click handles.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates strong DOTA chelation with azide click reactivity in a PEG5 scaffold, specifically offering a versatile linker for radiolabeling, probe development, and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
