DOTA-mono-NHS tris (t-Bu ester), CAS 819869-77-7, is a popular compound for bioconjugation and imaging.
Quick Overview
- Name: 1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butylacetate-10-acetic acid mono (N-hydroxysuccinimide) ester.
- CAS Number: 819869-77-7.
- Chemical Formula: C26H44N4O8.
- Molecular Weight: 540.65 g/mol.
Key Applications
- Bioconjugation: The NHS ester easily reacts with primary amines, making it ideal for attaching DOTA to peptides, antibodies, or other biomolecules.
- Radiolabeling: DOTA binds metal ions, like gadolinium for MRI or Lutetium-177 for targeted radiotherapy.
- Imaging: This compound supports PET, SPECT, and MRI imaging agent development.
Important Properties
- NHS Ester: Highly reactive with primary amines for efficient labeling.
- tert-Butyl Ester Groups: These protect the DOTA carboxyl groups, ensuring stability until deprotection is necessary for metal binding.
- Chelating Power: DOTA binds tightly to various metal ions after deprotection.
Handling Tips
- Storage: Keep it cool and dry, away from moisture and light. This prevents hydrolysis of the NHS ester.
- Safety: Wear protective gear when handling. It’s reactive, especially with amine compounds.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
