DMT-2′-O-Methyl-rU Phosphoramidite
This product is a high-purity nucleotide building block designed for solid-phase RNA synthesis. It features a 2′-O-methyl modification on ribouridine, providing nuclease resistance, improved binding affinity, and enhanced stability specifically for synthetic oligonucleotides and therapeutic applications.
Key Features and Benefits:
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2′-O-Methyl Modification: Increases nuclease resistance and duplex stability.
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Uridine Base: Preserves natural RNA recognition and binding properties.
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DMT Protection: Enables efficient incorporation during automated oligonucleotide synthesis.
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Phosphoramidite Functionality: Compatible with standard solid-phase synthesis protocols.
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High Purity: Guarantees reproducibility for research and therapeutic applications.
Applications:
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RNA Oligonucleotide Synthesis: Incorporation of 2′-O-methyl uridine into synthetic RNA strands.
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siRNA and ASO Design: Enhances nuclease resistance and improves pharmacokinetics.
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Therapeutics Development: Useful in antisense, aptamer, and RNA-based drug discovery.
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Molecular Biology Research: Facilitates synthesis of stable, modified oligonucleotides for structural and functional studies.
Storage and Handling:
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Storage: Store dry at –20 °C in a tightly sealed container, under inert atmosphere.
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Handling: Use standard phosphoramidite synthesis conditions; avoid prolonged exposure to air or moisture.
This product provides enhanced nuclease resistance and stability, making it an essential nucleotide analog specifically for advanced RNA synthesis and therapeutic oligonucleotide development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
