DMT-2’O-Methyl-rU Phosphoramidite (CAS: 110764-79-9): Overview and Applications
DMT-2’O-Methyl-rU Phosphoramidite (CAS: 110764-79-9) is a modified nucleotide used in the synthesis of oligonucleotides. It features a dimethoxytrityl (DMT) protective group and a 2’O-methyl modification on ribouridine (rU), enhancing the stability and functionality of RNA sequences.
Key Features:
- DMT Group: Protects the 5′ hydroxyl, allowing for selective coupling during synthesis.
- 2’O-Methyl Modification: Increases stability against nucleases and improves hybridization properties.
- Ribouridine Base: Maintains the essential features of uridine while enhancing overall stability.
Applications:
- Oligonucleotide Synthesis: Ideal for synthesizing stable RNA sequences with improved resistance to degradation.
- Gene Expression Studies: Used in probes and primers for analyzing RNA expression and regulation.
- Antisense Oligonucleotides: Provides enhanced stability for therapeutic applications.
- Diagnostics: Supports the development of RNA-based diagnostic assays.
DMT-2’O-Methyl-rU Phosphoramidite is essential for creating modified oligonucleotides in research, diagnostics, and therapeutic development.
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