DBCO-Val-Cit-PAB-OH
This product is a heterobifunctional linker combining a dibenzocyclooctyne (DBCO) group for copper-free SPAAC click chemistry with a protease-cleavable Val–Cit dipeptide and self-immolative PAB spacer. This design enables targeted release, making it especially effective in ADC development, drug delivery, and bioconjugation workflows.
Key Features and Benefits:
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DBCO Group: Supports rapid, catalyst-free SPAAC click chemistry with azides.
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Val–Cit Dipeptide: Cleaved by cathepsin B in tumor microenvironments.
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PAB Spacer: Self-immolative group for efficient payload release.
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PEGylated Scaffold: Improves solubility and flexibility.
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High Purity: Ensures reproducibility in therapeutic development.
Applications:
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Antibody–Drug Conjugates (ADCs): Provides tumor-selective, cleavable linker systems.
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Drug Delivery: Enables controlled release of therapeutic payloads.
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Bioconjugation: Combines click chemistry with protease-sensitive cleavage.
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Probe Development: Supports targeted imaging and diagnostic tools.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged hydrolysis.
This product combines SPAAC click chemistry with protease-cleavable Val–Cit and self-immolative PAB, specifically offering versatility for drug delivery and ADC linker design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
