DBCO-PEG8-Val-Cit-PAB-PNP is a versatile and innovative cleavable DBCO linker molecule designed for application in pharmaceutical research and development. Comprising of a dibenzocyclooctyne (DBCO) moiety, a polyethylene glycol (PEG8) spacer, and a Valine-Citrulline-PABA-PNP (Val-Cit-PAB-PNP) cleavable linker, this compound offers precise control and targeted release of therapeutic agents in biological systems.
The DBCO group enables bioorthogonal copper-free click chemistry, facilitating the conjugation of drug molecules or biomolecules with minimal interference in biological processes. The PEG8 spacer enhances solubility and reduces aggregation, while the Val-Cit-PAB-PNP linker, which is specifically cleaved by the enzyme cathepsin B, enables targeted drug release in the presence of this enzyme, often overexpressed in tumor cells.
DBCO-PEG8-Val-Cit-PAB-PNP is ideal for the development of antibody-drug conjugates (ADCs) and other targeted therapeutics, contributing to more effective and safer treatments with reduced side effects for patients.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
