DBCO-PEG8-NHS ester
This product is a high-purity heterobifunctional PEG linker with a dibenzocyclooctyne (DBCO) for rapid, copper-free SPAAC click chemistry and an NHS ester for efficient amine coupling. Its PEG8 spacer improves solubility, flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems specifically for applications in bioorthogonal labeling, drug delivery, and advanced material functionalization.
Key Features and Benefits
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DBCO Group: Enables rapid, catalyst-free SPAAC click chemistry with azides, ideal for sensitive biological systems.
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NHS Ester: Reacts efficiently with primary amines for stable amide bond formation.
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PEG8 Spacer: Enhances solubility, flexibility, and accessibility of reactive groups while reducing steric hindrance.
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Heterobifunctional Design: Allows orthogonal conjugations for controlled and site-specific modifications.
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High Purity: Supplied at >95% purity for reproducible and reliable results.
Applications
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Copper-free bioorthogonal labeling and conjugation.
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Antibody–drug conjugate (ADC) and protein modification workflows.
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Nanoparticle and surface functionalization.
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Development of targeted drug delivery systems.
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Functional biomaterials and hydrogel crosslinking.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve NHS ester reactivity.
This product combines a copper-free DBCO click handle with an NHS ester for amine conjugation, linked by a PEG8 spacer for optimal solubility and flexibility, especially ideal for orthogonal bioconjugation in drug delivery, biomaterials, and bioimaging.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
