DBCO-PEG4-SS-TCO is a cleavable linker used in bioconjugation. It has a DBCO group for copper-free click chemistry with azides, a TCO moiety for rapid reaction with tetrazines, a PEG4 spacer for better solubility and flexibility, and a disulfide bond for controlled release under reducing conditions.
Key Features:
- DBCO Group: Enables copper-free click reactions with azides.
- TCO Moiety: Reacts efficiently with tetrazine groups.
- PEG4 Spacer: Improves solubility and reduces steric hindrance.
- Disulfide Bond: Allows controlled release under reducing conditions.
Applications:
- Antibody-Drug Conjugates (ADCs): Links drugs to antibodies for targeted therapy.
- Protein and Peptide Conjugation: Attaches proteins or peptides to surfaces.
- Surface Functionalization: Adds functional groups for biosensor applications.
Store at -20°C and dissolve in DCM, THF, acetonitrile, DMF, or DMSO.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
