DBCO-PEG4-Amine
DBCO-PEG4-Amine is a high-purity heterobifunctional PEG linker with a DBCO group for copper-free strain-promoted alkyne–azide cycloaddition (SPAAC) and a primary amine for versatile conjugation. The PEG4 spacer improves aqueous solubility, flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. This design is ideal for orthogonal labeling, multifunctional bioconjugates, and targeted delivery systems.
Key Features and Benefits
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DBCO Group: Supports copper-free click chemistry with azides for bioorthogonal conjugation.
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Primary Amine: Enables versatile coupling with NHS esters, activated acids, and other electrophiles.
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PEG4 Spacer: Enhances solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Allows sequential and orthogonal modification strategies.
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High Purity: Supplied at >95% purity for reliable and reproducible performance.
Applications
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Bioorthogonal click labeling with azide-containing molecules.
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Protein, peptide, and small molecule conjugation.
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Antibody–drug conjugates (ADCs).
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Nanoparticle and surface modification.
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Multifunctional imaging and diagnostic probes.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve amine reactivity.
DBCO-PEG4-Amine combines SPAAC click chemistry with primary amine versatility, enhanced by a PEG4 spacer specifically for improved solubility and flexibility, making it ideal for multifunctional bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
