DBCO PEG4 Amine CAS# 1840886-10-3: Key Benefits and Uses
What is DBCO PEG4 Amine? DBCO PEG4 amine is a powerful chemical tool used in bioconjugation and chemical biology. It combines:
- DBCO (Dibenzocyclooctyne): A reactive group that allows for efficient and selective conjugation with azide-containing molecules.
- PEG4 (Polyethylene Glycol with a 4-unit Chain): A flexible spacer that improves solubility and stability.
- Amine Group: A site for further chemical modifications or conjugations.
Advantages of DBCO PEG4 Amine
- Efficient Conjugation: DBCO reacts strongly with azides, ensuring effective and precise bioconjugation.
- No Copper Catalyst Required: Simplifies the reaction process and avoids potential toxicity associated with copper catalysts.
- Enhanced Solubility and Stability: The PEG4 spacer enhances solubility in water and increases the stability of the conjugated products.
- Reduced Steric Hindrance: The PEG4 linker reduces steric hindrance, which improves the efficiency of the conjugation process.
- Versatile Chemical Modifications: The amine group allows for further chemical modifications, making it ideal for complex molecule and drug delivery system design.
- Biocompatibility: PEG4 is biocompatible and reduces the risk of immunogenicity, making it suitable for biological applications.
- High Specificity and Yield: Provides controlled reactions with minimal by-products, leading to well-defined conjugation products.
Applications of DBCO PEG4 Amine
- Chemical Biology: For precise labeling and tracking of biomolecules.
- Pharmaceuticals: In developing targeted drug delivery systems.
- Molecular Imaging: Enhances imaging techniques through accurate bioconjugation.
DBCO PEG4 amine is a versatile and effective tool for advanced research and development in various fields.
Ref:
Saini, G., Parasa, M.K., Clayton, K.N. et al. Immobilization of azide-functionalized proteins to micro- and nanoparticles directly from cell lysate. Microchim Acta 191, 46 (2024).
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
