DBCO-PEG4-acetic-EVCit-PAB

DBCO-PEG4-acetic-EVCit-PAB is a bioconjugation linker designed for drug delivery and antibody-drug conjugates (ADCs). It features a DBCO group for click chemistry, a PEG4 spacer for solubility, and a cleavable EVCit-PAB linker that enables targeted drug release in cancer therapy.

Key Features

1. DBCO Group – Enables fast, copper-free click chemistry for bioorthogonal conjugation.
2. PEG4 Spacer – Improves solubility and reduces steric hindrance for efficient linking.
3. Cleavable EVCit-PAB Linker – Enzymatically broken down in tumor environments for controlled drug release.
4. Acetic Acid Termination – Enhances stability and modulates conjugation efficiency.
5. Optimized for Drug Development – Commonly used in ADCs and targeted therapeutics.

Applications

1. Antibody-Drug Conjugates (ADCs) – Used as a cleavable linker for precise drug release.
2. Bioorthogonal Chemistry – Enables efficient, copper-free bioconjugation in biological systems.
3. Targeted Drug Delivery – Designed for controlled payload release in cancer treatment.
4. Protein & Peptide Labeling – Enhances stability and functionality in bioconjugation.
5. Nanoparticle Functionalization – Improves surface modification for imaging and therapy.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.