DBCO-PEG3-propionic-Val-Cit-PAB
This product is a cleavable linker frequently used in antibody-drug conjugates (ADCs) and targeted drug delivery systems. Specifically, it combines a DBCO group for copper-free click chemistry, a PEG3 spacer to enhance solubility, and a Val-Cit-PAB moiety for controlled intracellular drug release. As a result, this reagent enables site-specific conjugation and cathepsin B-triggered payload release.
Key Features and Benefits:
-
Click Chemistry Ready: DBCO allows rapid, copper-free reaction with azide-modified biomolecules.
-
PEG3 Spacer: Improves solubility, reduces aggregation, and enhances biocompatibility.
-
Val-Cit-PAB Cleavable Linker: Cathepsin B-sensitive dipeptide enables precise drug release inside target cells.
-
Self-Immolative Mechanism: Ensures complete payload release following cleavage.
-
ADC-Compatible: Widely used in antibody-drug conjugate development for cancer and immunotherapy applications.
Applications:
-
Antibody-Drug Conjugates (ADCs): Facilitates stable conjugation and controlled release of cytotoxic agents.
-
Targeted Drug Delivery: Enables selective drug activation in diseased cells.
-
Click Chemistry Bioconjugation: Ideal for bioorthogonal labeling in live cell and in vivo environments.
-
Preclinical Research: Validated linker design for use in therapeutic development pipelines.
Storage and Handling:
-
Storage: Store at -20°C, protected from light and moisture.
-
Handling: Use anhydrous solvents (e.g., DMSO, DMF); prepare fresh solutions to avoid hydrolysis.
DBCO-PEG3-propionic-Val-Cit-PAB offers efficient conjugation, excellent solubility, and reliable intracellular drug release, making it a powerful tool for advancing next-generation targeted therapeutics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
