DBCO-PEG24-NHS Ester (CAS: 2765066-38-2) is a versatile PEG-based linker used in bioconjugation and click chemistry. It features a DBCO group for copper-free click reactions and an NHS ester for amine coupling, connected by a long, flexible PEG24 spacer.
Key Features:
- DBCO Group: Enables copper-free click reactions with azide-functionalized molecules for fast and efficient conjugation.
- NHS Ester: Reacts with primary amines on biomolecules like proteins and peptides, forming stable amide bonds.
- PEG24 Spacer: Improves water solubility, flexibility, and reduces steric hindrance for enhanced coupling efficiency.
Applications:
- Bioconjugation: Links proteins, peptides, and nucleic acids for drug development and diagnostics.
- Surface Functionalization: Modifies nanoparticles, microspheres, or other surfaces for further biofunctionalization.
- Drug Delivery Systems: Attaches therapeutic agents to targeting molecules for advanced drug delivery platforms.
How to Use:
- Storage: Store at -20°C, protected from light and moisture.
- Solubility: Dissolves well in organic solvents like DMSO and DMF, depending on the application.
DBCO-PEG-NHS Ester offers a powerful solution for creating stable, biofunctional conjugates with excellent solubility and minimal steric hindrance.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
