DBCO-PEG-Thiol(DBCO-PEG-SH), MW 1K, The DBCO group, also known as an alkyne group, is a highly reactive functional group that can undergo a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction with azide groups to form a stable triazole linkage. This reaction, also known as click chemistry, has emerged as a powerful tool for bioconjugation and drug delivery applications.
The PEG group is a hydrophilic polymer that can improve the solubility, stability, and pharmacokinetic properties of drugs. By conjugating drugs with PEG, researchers can enhance their circulation time, reduce immunogenicity, and improve their therapeutic index.
Thiol group is a sulfur-containing functional group that can react with various electrophiles, such as maleimides and vinyl sulfones, to form covalent bonds. Thiol-reactive molecules are widely used for the site-specific modification of proteins, antibodies, and other biomolecules.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.