DBCO-NH-PEG4-NHS ester
This high-purity PEG linker features a dibenzocyclooctyne (DBCO) for rapid, copper-free SPAAC click chemistry and an NHS ester for efficient amine coupling. The PEG4 spacer improves solubility, flexibility, and reduces steric hindrance for efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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DBCO Group – Supports copper-free SPAAC click chemistry with azide-containing biomolecules.
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NHS Ester – Reacts efficiently with primary amines on proteins, peptides, and other biomolecules.
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PEG4 Spacer – Improves solubility and accessibility of reactive groups while minimizing steric hindrance.
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Orthogonal Reactivity – Allows sequential and site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for consistent and reproducible results.
Applications
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Bioorthogonal labeling of proteins, peptides, and nucleic acids
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Antibody–drug conjugate (ADC) linker chemistry
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Site-specific modification for drug delivery systems
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Multifunctional imaging and diagnostic probe development
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture to preserve NHS ester reactivity
This product combines copper-free click chemistry via DBCO with efficient amine coupling through NHS ester chemistry, linked by a PEG4 spacer for solubility and flexibility, making it especially ideal for precise, orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
