DBCO-Mal (Dibenzocyclooctyne-Maleimide, or DBCO-Maleimide) is a powerful reagent for copper-free click chemistry and thiol-specific conjugation. It combines a DBCO group for rapid reaction with azides and a maleimide group that targets thiol groups on cysteine residues.
Key Features:
- DBCO Group: Reacts quickly with azides, enabling copper-free and biocompatible labeling.
- Maleimide Group: Binds selectively to thiol groups, perfect for targeting cysteine residues in proteins.
- Dual Functionality: Offers flexible labeling options for proteins, peptides, and other biomolecules.
Applications:
- Bioconjugation: Efficiently labels proteins and peptides through targeted reactions with azides and thiols.
- Drug Delivery: Connects therapeutic agents to specific biomolecules for precise delivery.
- Live-Cell Imaging: Facilitates safe labeling without the need for copper, suitable for live-cell and in vivo applications.
Benefits:
- Copper-Free: Safe for sensitive biological environments; no toxic catalysts required.
- Thiol-Specific: Precisely targets cysteine residues, enhancing conjugation accuracy.
- Versatile: DBCO-Mal supports dual-targeting strategies, expanding its use in biotech and pharmaceuticals.
Storage and Handling:
- Store at -20°C in a dry, inert environment.
- Handle with standard safety precautions for reactive chemicals.
DBCO-Mal delivers high reactivity and versatility, making it essential for bioconjugation, molecular biology, and targeted drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
